Security software may mistakenly quarantine game files. Add the Resident Evil 6 installation folder as an exclusion in your antivirus settings or Windows Security.
Modding is popular in RE6 (costume swaps, gameplay overhauls), but mods are the #1 cause of "Failed Open File" after file verification. resident evil 6 fatal error failed open file
You might see this error displayed in slightly different ways: Security software may mistakenly quarantine game files
If the error specifically mentions a "movie" file, navigate to the game folder, open nativePC > movie , and ensure the folders (like 00 or 01 ) contain their respective .wmv files. If a folder is empty, copy files from other numbered folders as a temporary fix. System and Configuration Fixes navigate to the game folder